Path ID: DB06237_MESH_D007172_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C553414 | avanafil | Drug |
| UniProt:O76074 | cGMP-specific 3’,5’-cyclic phosphodiesterase | Protein |
| GO:0046069 | cGMP catabolic process | BiologicalProcess |
| MESH:D006152 | Cyclic GMP | ChemicalSubstance |
| GO:0044557 | relaxation of smooth muscle | BiologicalProcess |
| GO:0008015 | blood circulation | BiologicalProcess |
| MESH:D007172 | Erectile Dysfunction | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Avanafil | DECREASES ACTIVITY OF | Cgmp-Specific 3’,5’-Cyclic Phosphodiesterase |
| Cgmp-Specific 3’,5’-Cyclic Phosphodiesterase | POSITIVELY REGULATES | Cgmp Catabolic Process |
| Cgmp Catabolic Process | DECREASES ABUNDANCE OF | Cyclic Gmp |
| Cyclic Gmp | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Relaxation Of Smooth Muscle | POSITIVELY CORRELATED WITH | Blood Circulation |
| Blood Circulation | NEGATIVELY CORRELATED WITH | Erectile Dysfunction |
Reference: