Path ID: DB06212_MESH_D007177_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C116664 | tolvaptan | Drug |
| UniProt:P30518 | Vasopressin V2 receptor | Protein |
| reactome:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Pathway |
| GO:0070295 | renal water absorption | BiologicalProcess |
| MESH:D007177 | Inappropriate ADH Syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tolvaptan | NEGATIVELY REGULATES | Vasopressin V2 Receptor |
| Vasopressin V2 Receptor | PARTICIPATES IN | Vasopressin Regulates Renal Water Homeostasis Via Aquaporins |
| Vasopressin Regulates Renal Water Homeostasis Via Aquaporins | POSITIVELY REGULATES | Renal Water Absorption |
| Renal Water Absorption | POSITIVELY CORRELATED WITH | Inappropriate Adh Syndrome |
Comment: This disease is also known as Syndrome of inappropriate vasopressin secretion as per the original file. Tolvaptan is also known as aquaretic (https://en.wikipedia.org/wiki/Aquaretic). Note that hyponatremia corresponds to the state where water content is relatively large for the sodium content available (https://pubmed.ncbi.nlm.nih.gov/19322975/), which is possibly due to increased water reabsorption.
Reference: