Path ID: DB06212_MESH_D007010_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C116664 | tolvaptan | Drug |
| UniProt:P30518 | Vasopressin V2 receptor | Protein |
| reactome:R-HSA-432040 | Vasopressin regulates renal water homeostasis via Aquaporins | Pathway |
| GO:0070295 | renal water absorption | BiologicalProcess |
| MESH:D007010 | Hyponatremia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tolvaptan | NEGATIVELY REGULATES | Vasopressin V2 Receptor |
| Vasopressin V2 Receptor | PARTICIPATES IN | Vasopressin Regulates Renal Water Homeostasis Via Aquaporins |
| Vasopressin Regulates Renal Water Homeostasis Via Aquaporins | POSITIVELY REGULATES | Renal Water Absorption |
| Renal Water Absorption | POSITIVELY CORRELATED WITH | Hyponatremia |
Comment: Tolvaptan is also known as aquaretic (https://en.wikipedia.org/wiki/Aquaretic). Note that hyponatremia corresponds to the state where water content is relatively large for the sodium content available (https://pubmed.ncbi.nlm.nih.gov/19322975/), which is possibly due to increased water reabsorption. There are different types of hyponatremia, and medications like tolvaptan should only be used in those patients with high volume or normal volume hyponatremia (https://en.wikipedia.org/wiki/Hyponatremia#Medications).
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