Path ID: DB06211_MESH_D002764_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C099245 | Doripenem | Drug |
| InterPro:IPR001460 | Penicillin-binding protein, transpeptidase | GeneFamily |
| GO:0018104 | Cross-linking of the peptidoglycan | BiologicalProcess |
| GO:0009273 | Peptidoglycan-based cell wall biogenesis | BiologicalProcess |
| GO:0005618 | Cell wall | CellularComponent |
| taxonomy:2 | Bacteria | OrganismTaxon |
| MESH:D002764 | Cholecystitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Doripenem | DECREASES ACTIVITY OF | Penicillin-Binding Protein, Transpeptidase |
| Penicillin-Binding Protein, Transpeptidase | POSITIVELY REGULATES | Cross-Linking Of The Peptidoglycan |
| Cross-Linking Of The Peptidoglycan | POSITIVELY REGULATES | Peptidoglycan-Based Cell Wall Biogenesis |
| Peptidoglycan-Based Cell Wall Biogenesis | HAS OUTPUT | Cell Wall |
| Cell Wall | OCCURS IN | Bacteria |
| Bacteria | OCCURS IN | Cholecystitis |
Comment: The FDA revised the doripenem label in 2014 to include a warning against use in ventilator-associated pneumonia and to reiterate its safety and efficacy for its approved indications.
Reference: