Path ID: DB06201_MESH_D065768_2

db06201-mesh-d065768-2

Concepts

Identifier Name Type
MESH:C079703 rufinamide Drug
UniProt:P41594 Metabotropic glutamate receptor 5 Protein
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential MolecularActivity
GO:0035249 synaptic transmission, glutamatergic BiologicalProcess
HP:0032792 Tonic seizure PhenotypicFeature
MESH:D065768 Lennox-Gastaut syndrome Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Rufinamide DECREASES ACTIVITY OF Metabotropic Glutamate Receptor 5
Metabotropic Glutamate Receptor 5 POSITIVELY CORRELATED WITH G Protein-Coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential
G Protein-Coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential POSITIVELY CORRELATED WITH Synaptic Transmission, Glutamatergic
Synaptic Transmission, Glutamatergic POSITIVELY CORRELATED WITH Tonic Seizure
Tonic Seizure POSITIVELY CORRELATED WITH Lennox-Gastaut Syndrome

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