Path ID: DB06151_MESH_D000686_2
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000111 | acetylcysteine | Drug |
| CHEBI:15356 | cysteine | ChemicalSubstance |
| CHEBI:16856 | glutathione | ChemicalSubstance |
| MESH:D000686 | Amyloidosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Acetylcysteine | HAS METABOLITE | Cysteine |
| Cysteine | POSITIVELY CORRELATED WITH | Glutathione |
| Glutathione | NEGATIVELY CORRELATED WITH | Amyloidosis |
Comment: It’s not clear how (or if at all) acetylcysteine can be used in the treatment of Amyloidosis. If so, it could be due to as a precursor in the formation of glutathione (https://en.wikipedia.org/wiki/Acetylcysteine#Chemistry), which in turn could have a role in depleting the occurrence of protein aggregation (https://pubmed.ncbi.nlm.nih.gov/15857408/, https://pubmed.ncbi.nlm.nih.gov/33758187/)..)
Reference: