Path ID: DB06148_MESH_D003865_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008803 | mianserin | Drug |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| UniProt:P08913 | Alpha-2A adrenergic receptor | Protein |
| UniProt:P18825 | Alpha-2C adrenergic receptor | Protein |
| UniProt:P35367 | Histamine H1 receptor | Protein |
| MESH:D009638 | noradrenaline | ChemicalSubstance |
| GO:0051620 | Noradrenaline uptake | BiologicalProcess |
| GO:0023041 | Neuronal activation | BiologicalProcess |
| MESH:D012701 | Serotonin | ChemicalSubstance |
| GO:0032099 | Negative regulation of appetite | BiologicalProcess |
| HP:0000739 | Anxiety | PhenotypicFeature |
| HP:0002360 | Sleep disturbance | PhenotypicFeature |
| MESH:D003865 | Major depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mianserin | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Mianserin | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2C |
| Mianserin | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Mianserin | DECREASES ACTIVITY OF | Alpha-2A Adrenergic Receptor |
| Mianserin | DECREASES ACTIVITY OF | Alpha-2C Adrenergic Receptor |
| Mianserin | DECREASES ACTIVITY OF | Histamine H1 Receptor |
| Sodium-Dependent Noradrenaline Transporter | PARTICIPATES IN | Noradrenaline Uptake |
| Noradrenaline Uptake | DECREASES ABUNDANCE OF | Noradrenaline |
| Noradrenaline | PARTICIPATES IN | Neuronal Activation |
| Neuronal Activation | NEGATIVELY CORRELATED WITH | Major Depressive Disorder |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY CORRELATED WITH | Serotonin |
| 5-Hydroxytryptamine Receptor 2C | POSITIVELY CORRELATED WITH | Serotonin |
| Alpha-2A Adrenergic Receptor | CORRELATED WITH | Major Depressive Disorder |
| Alpha-2C Adrenergic Receptor | CORRELATED WITH | Major Depressive Disorder |
| Histamine H1 Receptor | POSITIVELY CORRELATED WITH | Anxiety |
| Serotonin | POSITIVELY CORRELATED WITH | Negative Regulation Of Appetite |
| Serotonin | POSITIVELY CORRELATED WITH | Anxiety |
| Serotonin | POSITIVELY CORRELATED WITH | Sleep Disturbance |
| Negative Regulation Of Appetite | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
| Anxiety | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
| Sleep Disturbance | POSITIVELY CORRELATED WITH | Major Depressive Disorder |
Reference: