Path ID: DB06144_MESH_D012559_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C066304 | sertindole | Drug |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| UniProt:P28223 | 5-hydroxytryptamine receptor 2A | Protein |
| UniProt:P28335 | 5-hydroxytryptamine receptor 2C | Protein |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| GO:0014046 | dopamine secretion | BiologicalProcess |
| GO:0014047 | glutamate secretion | BiologicalProcess |
| GO:0004952 | dopamine neurotransmitter receptor activity | MolecularActivity |
| UBERON:0001910 | medial forebrain bundle | GrossAnatomicalStructure |
| HP:0000709 | Psychosis | PhenotypicFeature |
| HP:0002071 | Abnormality of extrapyramidal motor function | PhenotypicFeature |
| MESH:D012559 | Schizophrenia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Sertindole | DECREASES ACTIVITY OF | D(2) Dopamine Receptor |
| Sertindole | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2C |
| Sertindole | DECREASES ACTIVITY OF | 5-Hydroxytryptamine Receptor 2A |
| Sertindole | DECREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Sertindole | DECREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Sertindole | DECREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | CORRELATED WITH | Abnormality Of Extrapyramidal Motor Function |
| Alpha-1D Adrenergic Receptor | CORRELATED WITH | Abnormality Of Extrapyramidal Motor Function |
| Alpha-1B Adrenergic Receptor | CORRELATED WITH | Abnormality Of Extrapyramidal Motor Function |
| Abnormality Of Extrapyramidal Motor Function | CORRELATED WITH | Schizophrenia |
| 5-Hydroxytryptamine Receptor 2C | NEGATIVELY REGULATES | Dopamine Secretion |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY REGULATES | Dopamine Secretion |
| 5-Hydroxytryptamine Receptor 2A | POSITIVELY REGULATES | Glutamate Secretion |
| Glutamate Secretion | POSITIVELY CORRELATED WITH | Dopamine Neurotransmitter Receptor Activity |
| Dopamine Neurotransmitter Receptor Activity | POSITIVELY CORRELATED WITH | Psychosis |
| D(2) Dopamine Receptor | POSITIVELY REGULATES | Dopamine Secretion |
| Dopamine Secretion | LOCATED IN | Medial Forebrain Bundle |
| Dopamine Secretion | NEGATIVELY CORRELATED WITH | Schizophrenia |
| Medial Forebrain Bundle | POSITIVELY CORRELATED WITH | Schizophrenia |
| Psychosis | POSITIVELY CORRELATED WITH | Schizophrenia |
Reference: