Path ID: DB05812_MESH_D011471_6

db05812-mesh-d011471-6

Concepts

Identifier Name Type
DB:DB05812 abiraterone acetate Drug
MESH:C000600172 delta4-abiraterone Drug
UniProt:P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Protein
UniProt:P31213 3-oxo-5-alpha-steroid 4-dehydrogenase 2 Protein
UniProt:Q9H8P0 Polyprenol reductase Protein
GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor MolecularActivity
CHEBI:16330 17β-hydroxy-5α-androstan-3-one ChemicalSubstance
MESH:D011471 Malignant tumor of prostate Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Abiraterone Acetate DERIVES INTO Delta4-Abiraterone
Delta4-Abiraterone DECREASES ACTIVITY OF 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 1
Delta4-Abiraterone DECREASES ACTIVITY OF 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2
Delta4-Abiraterone DECREASES ACTIVITY OF Polyprenol Reductase
3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 1 POSITIVELY REGULATES Steroid Dehydrogenase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor
3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 POSITIVELY REGULATES Steroid Dehydrogenase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor
Polyprenol Reductase POSITIVELY REGULATES Steroid Dehydrogenase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor
Steroid Dehydrogenase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor PRODUCES 17Β-Hydroxy-5Α-Androstan-3-One
17Β-Hydroxy-5Α-Androstan-3-One POSITIVELY CORRELATED WITH Malignant Tumor Of Prostate

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