Path ID: DB05812_MESH_D011471_5
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB05812 | abiraterone acetate | Drug |
| MESH:C000600172 | delta4-abiraterone | Drug |
| UniProt:P05093 | Steroid 17-alpha-hydroxylase/17,20 lyase | Protein |
| UniProt:P26439 | 3 beta-hydroxysteroid dehydrogenase/Delta 5–>4-isomerase type 2 | Protein |
| UniProt:P14060 | 3 beta-hydroxysteroid dehydrogenase/Delta 5–>4-isomerase type 1 | Protein |
| GO:0006702 | androgen biosynthetic process | BiologicalProcess |
| GO:0006704 | glucocorticoid biosynthetic process | BiologicalProcess |
| HP:0030088 | Increased serum testosterone level | PhenotypicFeature |
| MESH:D011471 | Malignant tumor of prostate | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Abiraterone Acetate | DERIVES INTO | Delta4-Abiraterone |
| Delta4-Abiraterone | NEGATIVELY REGULATES | Steroid 17-Alpha-Hydroxylase/17,20 Lyase |
| Delta4-Abiraterone | NEGATIVELY REGULATES | 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2 |
| Delta4-Abiraterone | NEGATIVELY REGULATES | 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1 |
| Steroid 17-Alpha-Hydroxylase/17,20 Lyase | POSITIVELY REGULATES | Androgen Biosynthetic Process |
| 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2 | POSITIVELY REGULATES | Androgen Biosynthetic Process |
| 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1 | POSITIVELY REGULATES | Androgen Biosynthetic Process |
| Steroid 17-Alpha-Hydroxylase/17,20 Lyase | POSITIVELY REGULATES | Glucocorticoid Biosynthetic Process |
| 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2 | POSITIVELY REGULATES | Glucocorticoid Biosynthetic Process |
| 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1 | POSITIVELY REGULATES | Glucocorticoid Biosynthetic Process |
| Glucocorticoid Biosynthetic Process | POSITIVELY CORRELATED WITH | Increased Serum Testosterone Level |
| Androgen Biosynthetic Process | POSITIVELY CORRELATED WITH | Increased Serum Testosterone Level |
| Increased Serum Testosterone Level | POSITIVELY CORRELATED WITH | Malignant Tumor Of Prostate |
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