Path ID: DB05812_MESH_D011471_4
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069501 | abiraterone acetate | Drug |
| UniProt:P10275 | Androgen receptor | Protein |
| GO:0060767 | epithelial cell proliferation involved in prostate gland development | BiologicalProcess |
| MESH:D011471 | Malignant tumor of prostate | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Abiraterone Acetate | DECREASES ACTIVITY OF | Androgen Receptor |
| Androgen Receptor | POSITIVELY REGULATES | Epithelial Cell Proliferation Involved In Prostate Gland Development |
| Epithelial Cell Proliferation Involved In Prostate Gland Development | POSITIVELY CORRELATED WITH | Malignant Tumor Of Prostate |
Comment: In addition to inhibiting UniProt:P05093 (the main target according to https://go.drugbank.com/drugs/DB05812#mechanism-of-action),,) abiraterone also acts as a partial antagonist of the androgen receptor (UniProt:P10275).
Reference: