Path ID: DB05812_MESH_D011471_1

db05812-mesh-d011471-1

Concepts

Identifier Name Type
DB:DB05812 abiraterone acetate Drug
UniProt:P05093 Steroid 17-alpha-hydroxylase/17,20 lyase Protein
UniProt:P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5–>4-isomerase type 2 Protein
UniProt:P14060 3 beta-hydroxysteroid dehydrogenase/Delta 5–>4-isomerase type 1 Protein
GO:0006702 androgen biosynthetic process BiologicalProcess
GO:0006704 glucocorticoid biosynthetic process BiologicalProcess
HP:0030088 Increased serum testosterone level PhenotypicFeature
MESH:D011471 Malignant tumor of prostate Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Abiraterone Acetate NEGATIVELY REGULATES Steroid 17-Alpha-Hydroxylase/17,20 Lyase
Abiraterone Acetate NEGATIVELY REGULATES 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2
Abiraterone Acetate NEGATIVELY REGULATES 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1
Steroid 17-Alpha-Hydroxylase/17,20 Lyase POSITIVELY REGULATES Androgen Biosynthetic Process
3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2 POSITIVELY REGULATES Androgen Biosynthetic Process
3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1 POSITIVELY REGULATES Androgen Biosynthetic Process
Steroid 17-Alpha-Hydroxylase/17,20 Lyase POSITIVELY REGULATES Glucocorticoid Biosynthetic Process
3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 2 POSITIVELY REGULATES Glucocorticoid Biosynthetic Process
3 Beta-Hydroxysteroid Dehydrogenase/Delta 5–>4-Isomerase Type 1 POSITIVELY REGULATES Glucocorticoid Biosynthetic Process
Glucocorticoid Biosynthetic Process POSITIVELY CORRELATED WITH Increased Serum Testosterone Level
Androgen Biosynthetic Process POSITIVELY CORRELATED WITH Increased Serum Testosterone Level
Increased Serum Testosterone Level POSITIVELY CORRELATED WITH Malignant Tumor Of Prostate

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