Path ID: DB05768_MESH_D007014_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB05768 | Asfotase alfa | Drug |
| UniProt:P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Protein |
| CHEBI:18361 | Diphosphate(4−) | ChemicalSubstance |
| CHEBI:52255 | Hydroxylapatite | ChemicalSubstance |
| GO:0030282 | Bone mineralization | BiologicalProcess |
| MESH:D007014 | Hypophosphatasia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Asfotase Alfa | SIMILAR TO | Alkaline Phosphatase, Tissue-Nonspecific Isozyme |
| Alkaline Phosphatase, Tissue-Nonspecific Isozyme | DECREASES ABUNDANCE OF | Diphosphate(4−) |
| Diphosphate(4−) | NEGATIVELY REGULATES | Hydroxylapatite |
| Hydroxylapatite | PARTICIPATES IN | Bone Mineralization |
| Bone Mineralization | NEGATIVELY CORRELATED WITH | Hypophosphatasia |
Reference: