Path ID: DB05676_MESH_D015535_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C505730 | Apremilast | Drug |
| UniProt:P27815 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4A | Protein |
| UniProt:Q07343 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4B | Protein |
| UniProt:Q08493 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4C | Protein |
| UniProt:Q08499 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D | Protein |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0032680 | Regulation of tumor necrosis factor production | BiologicalProcess |
| UniProt:P35228 | Nitric oxide synthase, inducible | Protein |
| GO:0032627 | Interleukin-23 production | BiologicalProcess |
| GO:0032613 | Interleukin-10 production | BiologicalProcess |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| MESH:D015535 | Psoriasis with arthropathy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Apremilast | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4A |
| Apremilast | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4B |
| Apremilast | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4C |
| Apremilast | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4D |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4A | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4A | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4B | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4C | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4D | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp Catabolic Process | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Regulation Of Tumor Necrosis Factor Production |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Nitric Oxide Synthase, Inducible |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Interleukin-23 Production |
| 3’,5’-Cyclic Amp | POSITIVELY REGULATES | Interleukin-10 Production |
| Regulation Of Tumor Necrosis Factor Production | POSITIVELY REGULATES | Inflammatory Response |
| Nitric Oxide Synthase, Inducible | POSITIVELY REGULATES | Inflammatory Response |
| Interleukin-23 Production | POSITIVELY REGULATES | Inflammatory Response |
| Interleukin-10 Production | NEGATIVELY REGULATES | Inflammatory Response |
| Inflammatory Response | CAUSES | Psoriasis With Arthropathy |
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