Path ID: DB05381_MESH_D015470_1

db05381-mesh-d015470-1

Concepts

Identifier Name Type
MESH:D006632 histamine Drug
UniProt:P60568 Interleukin-2 Protein
UniProt:P01589 Interleukin-2 receptor subunit alpha Protein
UniProt:P14784 Interleukin-2 receptor subunit beta Protein
UniProt:P31785 Cytokine receptor common subunit gamma Protein
reactome:R-HSA-9020558 Interleukin-2 signaling Pathway
GO:0045065 cytotoxic T cell differentiation BiologicalProcess
GO:0030101 natural killer cell activation BiologicalProcess
MESH:D015470 Leukemia, Myeloid, Acute Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Histamine INCREASES ACTIVITY OF Interleukin-2
Interleukin-2 INCREASES ACTIVITY OF Interleukin-2 Receptor Subunit Alpha
Interleukin-2 INCREASES ACTIVITY OF Interleukin-2 Receptor Subunit Beta
Interleukin-2 INCREASES ACTIVITY OF Cytokine Receptor Common Subunit Gamma
Interleukin-2 Receptor Subunit Alpha POSITIVELY REGULATES Interleukin-2 Signaling
Interleukin-2 Receptor Subunit Beta POSITIVELY REGULATES Interleukin-2 Signaling
Cytokine Receptor Common Subunit Gamma POSITIVELY REGULATES Interleukin-2 Signaling
Interleukin-2 Signaling POSITIVELY REGULATES Cytotoxic T Cell Differentiation
Interleukin-2 Signaling POSITIVELY REGULATES Natural Killer Cell Activation
Cytotoxic T Cell Differentiation NEGATIVELY CORRELATED WITH Leukemia, Myeloid, Acute
Natural Killer Cell Activation NEGATIVELY CORRELATED WITH Leukemia, Myeloid, Acute

Comment: Histamine dihydrochloride that is used in Leukemia, Myeloid, Acute treatment.

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