Path ID: DB05352_MESH_D000686_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C547076 | tafamidis | Drug |
| UniProt:P02766 | Transthyretin | Protein |
| GO:0042802 | identical protein binding | MolecularActivity |
| GO:0051262 | protein tetramerization | BiologicalProcess |
| GO:0043243 | positive regulation of protein-containing complex disassembly | BiologicalProcess |
| GO:1903333 | negative regulation of protein folding | BiologicalProcess |
| GO:1990000 | amyloid fibril formation | BiologicalProcess |
| MESH:D000686 | Amyloidosis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tafamidis | INCREASES STABILITY OF | Transthyretin |
| Transthyretin | ENABLES | Identical Protein Binding |
| Identical Protein Binding | CAUSES | Protein Tetramerization |
| Protein Tetramerization | DISRUPTED BY | Positive Regulation Of Protein-Containing Complex Disassembly |
| Positive Regulation Of Protein-Containing Complex Disassembly | CORRELATED WITH | Negative Regulation Of Protein Folding |
| Negative Regulation Of Protein Folding | EXACERBATES | Amyloid Fibril Formation |
| Amyloid Fibril Formation | CAUSES | Amyloidosis |
Comment: both Tafamidis and tafamidis meglumine (FX-1006A, which is drugbank:DB05352) are benzoxazole derivatives (https://go.drugbank.com/drugs/DB11644#description)
Reference: