Path ID: DB05271_MESH_D012148_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C047508 | rotigotine | Drug |
| UniProt:P35462 | D(3) dopamine receptor | Protein |
| UniProt:P21917 | D(4) dopamine receptor | Protein |
| UniProt:P14416 | D(2) dopamine receptor | Protein |
| UniProt:P21918 | D(1B) dopamine receptor | Protein |
| UniProt:P21728 | D(1A) dopamine receptor | Protein |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| HP:0002360 | Sleep disturbance | PhenotypicFeature |
| MESH:D012148 | Restless Legs Syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Rotigotine | INCREASES ACTIVITY OF | D(3) Dopamine Receptor |
| Rotigotine | INCREASES ACTIVITY OF | D(4) Dopamine Receptor |
| Rotigotine | INCREASES ACTIVITY OF | D(2) Dopamine Receptor |
| Rotigotine | INCREASES ACTIVITY OF | D(1B) Dopamine Receptor |
| Rotigotine | INCREASES ACTIVITY OF | D(1A) Dopamine Receptor |
| D(3) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| D(4) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| D(2) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| D(1B) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| D(1A) Dopamine Receptor | POSITIVELY CORRELATED WITH | Dopamine |
| Dopamine | NEGATIVELY CORRELATED WITH | Sleep Disturbance |
| Sleep Disturbance | MANIFESTATION OF | Restless Legs Syndrome |
Reference:
- https://go.drugbank.com/drugs/DB05271#mechanism-of-action
- https://en.wikipedia.org/wiki/Rotigotine#Pharmacology
- https://www.uniprot.org/uniprot/P35462#function
- https://www.uniprot.org/uniprot/P21917#function
- https://www.uniprot.org/uniprot/P14416#function
- https://www.uniprot.org/uniprot/P21918#function
- https://www.uniprot.org/uniprot/P21728#function
- https://en.wikipedia.org/wiki/Restless_legs_syndrome