Path ID: DB05266_MESH_D001249_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C038366 | Ibudilast | Drug |
| InterPro:IPR043371 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4 | GeneFamily |
| CHEBI:17489 | 3’,5’-cyclic AMP | ChemicalSubstance |
| GO:0006954 | Inflammatory response | BiologicalProcess |
| GO:0044557 | Relaxation of smooth muscle | BiologicalProcess |
| MESH:D001249 | Asthma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ibudilast | DECREASES ACTIVITY OF | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4 |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4 | DECREASES ABUNDANCE OF | 3’,5’-Cyclic Amp |
| 3’,5’-Cyclic Amp | NEGATIVELY REGULATES | Inflammatory Response |
| 3’,5’-Cyclic Amp | POSITIVELY REGULATES | Relaxation Of Smooth Muscle |
| Inflammatory Response | CAUSES | Asthma |
| Relaxation Of Smooth Muscle | NEGATIVELY CORRELATED WITH | Asthma |
Reference: