Path ID: DB05219_MESH_D003876_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C543085 | crisaborole | Drug |
| UniProt:P27815 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4A | Protein |
| UniProt:Q07343 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4B | Protein |
| UniProt:Q08493 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4C | Protein |
| UniProt:Q08499 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4D | Protein |
| GO:0006198 | cAMP catabolic process | BiologicalProcess |
| GO:0032680 | regulation of tumor necrosis factor production | BiologicalProcess |
| GO:0032674 | regulation of interleukin-5 production | BiologicalProcess |
| GO:0032663 | regulation of interleukin-2 production | BiologicalProcess |
| GO:0032673 | regulation of interleukin-4 production | BiologicalProcess |
| GO:0032649 | regulation of interferon-gamma production | BiologicalProcess |
| GO:0006955 | immune response | BiologicalProcess |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D003876 | Atopic dermatitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Crisaborole | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4A |
| Crisaborole | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4B |
| Crisaborole | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4C |
| Crisaborole | NEGATIVELY REGULATES | Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4D |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4A | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4B | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4C | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp-Specific 3’,5’-Cyclic Phosphodiesterase 4D | POSITIVELY CORRELATED WITH | Camp Catabolic Process |
| Camp Catabolic Process | POSITIVELY CORRELATED WITH | Regulation Of Tumor Necrosis Factor Production |
| Camp Catabolic Process | POSITIVELY CORRELATED WITH | Regulation Of Interleukin-5 Production |
| Camp Catabolic Process | POSITIVELY CORRELATED WITH | Regulation Of Interleukin-2 Production |
| Camp Catabolic Process | POSITIVELY CORRELATED WITH | Regulation Of Interleukin-4 Production |
| Camp Catabolic Process | POSITIVELY CORRELATED WITH | Regulation Of Interferon-Gamma Production |
| Regulation Of Tumor Necrosis Factor Production | POSITIVELY CORRELATED WITH | Immune Response |
| Regulation Of Interleukin-5 Production | POSITIVELY CORRELATED WITH | Immune Response |
| Regulation Of Interleukin-2 Production | POSITIVELY CORRELATED WITH | Immune Response |
| Regulation Of Interferon-Gamma Production | POSITIVELY CORRELATED WITH | Immune Response |
| Regulation Of Interleukin-4 Production | POSITIVELY CORRELATED WITH | Immune Response |
| Regulation Of Interleukin-4 Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Regulation Of Interferon-Gamma Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Regulation Of Interleukin-2 Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Regulation Of Interleukin-5 Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Regulation Of Tumor Necrosis Factor Production | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Immune Response | POSITIVELY CORRELATED WITH | Atopic Dermatitis |
| Inflammatory Response | POSITIVELY CORRELATED WITH | Atopic Dermatitis |
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