Path ID: DB05109_MESH_D007890_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C099150 | Trabectedin | Drug |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | BiologicalProcess |
| UniProt:P08183 | ATP-dependent translocase ABCB1 | Protein |
| GO:0007049 | Cell cycle | BiologicalProcess |
| MESH:D004247 | DNA | ChemicalSubstance |
| GO:0006281 | DNA repair | BiologicalProcess |
| HP:0020174 | Refractory drug response | PhenotypicFeature |
| GO:0008283 | Cell population proliferation | BiologicalProcess |
| MESH:D007890 | Leiomyosarcoma | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Trabectedin | NEGATIVELY REGULATES | Transcription-Coupled Nucleotide-Excision Repair |
| Trabectedin | DECREASES ACTIVITY OF | Atp-Dependent Translocase Abcb1 |
| Trabectedin | NEGATIVELY REGULATES | Cell Cycle |
| Trabectedin | DISRUPTS | Dna |
| Transcription-Coupled Nucleotide-Excision Repair | POSITIVELY REGULATES | Dna Repair |
| Atp-Dependent Translocase Abcb1 | POSITIVELY REGULATES | Refractory Drug Response |
| Cell Cycle | POSITIVELY REGULATES | Cell Population Proliferation |
| Dna | OCCURS IN | Leiomyosarcoma |
| Dna Repair | OCCURS IN | Leiomyosarcoma |
| Refractory Drug Response | OCCURS IN | Leiomyosarcoma |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Leiomyosarcoma |
Reference: