Path ID: DB04942_MESH_D015473_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C061133 | tamibarotene | Drug |
| UniProt:P10826 | Retinoic acid receptor beta | Protein |
| UniProt:P10276 | Retinoic acid receptor alpha | Protein |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| MESH:D015473 | Acute promyelocytic leukemia, FAB M3 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tamibarotene | POSITIVELY REGULATES | Retinoic Acid Receptor Beta |
| Tamibarotene | POSITIVELY REGULATES | Retinoic Acid Receptor Alpha |
| Retinoic Acid Receptor Beta | NEGATIVELY REGULATES | Cell Population Proliferation |
| Retinoic Acid Receptor Alpha | NEGATIVELY REGULATES | Cell Population Proliferation |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Acute Promyelocytic Leukemia, Fab M3 |
Comment: The drug has been approved in Japan but not yet in the US
Reference: