Path ID: DB04932_MESH_D006504_3
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C036901 | defibrotide | Drug |
| UniProt:P00750 | Tissue-type plasminogen activator | Protein |
| UniProt:P05121 | Plasminogen activator inhibitor 1 | Protein |
| GO:0007596 | blood coagulation | BiologicalProcess |
| HP:0002240 | Hepatomegaly | PhenotypicFeature |
| MESH:D006504 | Hepatic Veno-Occlusive Disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Defibrotide | INCREASES ACTIVITY OF | Tissue-Type Plasminogen Activator |
| Defibrotide | DECREASES ACTIVITY OF | Plasminogen Activator Inhibitor 1 |
| Tissue-Type Plasminogen Activator | NEGATIVELY REGULATES | Blood Coagulation |
| Plasminogen Activator Inhibitor 1 | POSITIVELY REGULATES | Blood Coagulation |
| Blood Coagulation | POSITIVELY CORRELATED WITH | Hepatomegaly |
| Hepatomegaly | CONTRIBUTES TO | Hepatic Veno-Occlusive Disease |
Reference:
- https://go.drugbank.com/drugs/DB04932#mechanism-of-action
- https://en.wikipedia.org/wiki/Defibrotide
- https://www.uniprot.org/uniprot/P00750#function
- https://www.uniprot.org/uniprot/P05121#function
- https://en.wikipedia.org/wiki/Tissue_plasminogen_activator
- https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1
- https://www.sciencedirect.com/topics/medicine-and-dentistry/plasminogen-activator-inhibitor
- https://en.wikipedia.org/wiki/Hepatic_veno-occlusive_disease