Path ID: DB04930_MESH_D012532_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D026023 | permethrin | Drug |
| UniProt:Q2VKV7 | Sodium channel protein | Protein |
| GO:1902305 | regulation of sodium ion transmembrane transport | BiologicalProcess |
| GO:0086009 | membrane repolarization | BiologicalProcess |
| MESH:D001369 | Axons | Cell |
| taxonomy:52283 | Sarcoptes scabiei | OrganismTaxon |
| MESH:D012532 | Infestation by Sarcoptes scabiei var hominis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Permethrin | DISRUPTS | Sodium Channel Protein |
| Sodium Channel Protein | POSITIVELY REGULATES | Regulation Of Sodium Ion Transmembrane Transport |
| Regulation Of Sodium Ion Transmembrane Transport | POSITIVELY CORRELATED WITH | Membrane Repolarization |
| Membrane Repolarization | OCCURS IN | Axons |
| Axons | IN TAXON | Sarcoptes Scabiei |
| Sarcoptes Scabiei | CAUSES | Infestation By Sarcoptes Scabiei Var Hominis |
Comment: DrugBank has this drug modulating a human target/protein (https://go.drugbank.com/drugs/DB04930#mechanism-of-action) instead of the non-vertebrate proteome. Because humans (and other mammals) share similar ion channels this drug can have some toxic effects on the vertebrate host (e.g. https://pubmed.ncbi.nlm.nih.gov/11812616/))
Reference:
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1525/
- https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4de55a80-67d6-42c0-a6fc-57b89400c5b3
- https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2362985/
- https://beta.targetvalidation.org/drug/CHEMBL1525
- https://en.wikipedia.org/wiki/Permethrin#Pharmacokinetics
- https://en.wikipedia.org/wiki/Pyrethroid#Mode_of_action