Path ID: DB04868_MESH_D015466_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C498826 | nilotinib | Drug |
| UniProt:P00519 | Tyrosine-protein kinase ABL1 | Protein |
| MESH:D016044 | Fusion Proteins, bcr-abl | Protein |
| GO:0004674 | protein serine/threonine kinase activity | MolecularActivity |
| GO:0007266 | Rho protein signal transduction | BiologicalProcess |
| GO:0008283 | cell population proliferation | BiologicalProcess |
| GO:0006915 | apoptotic process | BiologicalProcess |
| MESH:D015466 | Chronic phase chronic myeloid leukemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nilotinib | DECREASES ACTIVITY OF | Tyrosine-Protein Kinase Abl1 |
| Tyrosine-Protein Kinase Abl1 | PARTICIPATES IN | Fusion Proteins, Bcr-Abl |
| Fusion Proteins, Bcr-Abl | POSITIVELY REGULATES | Protein Serine/Threonine Kinase Activity |
| Protein Serine/Threonine Kinase Activity | POSITIVELY CORRELATED WITH | Rho Protein Signal Transduction |
| Rho Protein Signal Transduction | POSITIVELY CORRELATED WITH | Cell Population Proliferation |
| Rho Protein Signal Transduction | NEGATIVELY CORRELATED WITH | Apoptotic Process |
| Cell Population Proliferation | POSITIVELY CORRELATED WITH | Chronic Phase Chronic Myeloid Leukemia |
| Apoptotic Process | NEGATIVELY CORRELATED WITH | Chronic Phase Chronic Myeloid Leukemia |
Reference: