Path ID: DB04861_MESH_D006973_3
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000068577 | Nebivolol | Drug |
| UniProt:P13945 | Beta-3 adrenergic receptor | Protein |
| UniProt:P29474 | Nitric oxide synthase, endothelial | Protein |
| MESH:D009569 | Nitric Oxide | ChemicalSubstance |
| GO:0042311 | vasodilation | BiologicalProcess |
| HP:0032263 | Increased blood pressure | PhenotypicFeature |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nebivolol | INCREASES ACTIVITY OF | Beta-3 Adrenergic Receptor |
| Beta-3 Adrenergic Receptor | POSITIVELY CORRELATED WITH | Nitric Oxide Synthase, Endothelial |
| Nitric Oxide Synthase, Endothelial | INCREASES ABUNDANCE OF | Nitric Oxide |
| Nitric Oxide | POSITIVELY REGULATES | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Increased Blood Pressure |
| Increased Blood Pressure | MANIFESTATION OF | Hypertension |
Comment: Nebivolol is a highly selective beta-1 adrenergic receptor antagonist but it has some weak activity on beta-3 adrenergic receptor.
Reference:
- https://go.drugbank.com/drugs/DB04861#mechanism-of-action
- https://en.wikipedia.org/wiki/Nebivolol
- https://www.uniprot.org/uniprot/P13945#function
- https://www.uniprot.org/uniprot/P29474#function
- https://en.wikipedia.org/wiki/Beta3-adrenergic_agonist#Mechanism_of_action
- https://en.wikipedia.org/wiki/Nebivolol#Vasodilator_action
- https://en.wikipedia.org/wiki/Hypertension