Path ID: DB04855_MESH_D001281_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C118667 | dronedarone | Drug |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| InterPro:IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit | GeneFamily |
| UniProt:Q9Y3Q4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Protein |
| UniProt:P63252 | Inward rectifier potassium channel 2 | Protein |
| GO:0061337 | cardiac conduction | BiologicalProcess |
| HP:0001692 | Atrial arrhythmia | PhenotypicFeature |
| MESH:D001281 | Atrial fibrillation | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dronedarone | NEGATIVELY REGULATES | Voltage Gated Sodium Channel, Alpha Subunit |
| Dronedarone | NEGATIVELY REGULATES | Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit |
| Dronedarone | NEGATIVELY REGULATES | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 |
| Dronedarone | NEGATIVELY REGULATES | Inward Rectifier Potassium Channel 2 |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY REGULATES | Cardiac Conduction |
| Voltage-Dependent Calcium Channel, L-Type, Alpha-1 Subunit | POSITIVELY REGULATES | Cardiac Conduction |
| Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4 | POSITIVELY REGULATES | Cardiac Conduction |
| Inward Rectifier Potassium Channel 2 | POSITIVELY REGULATES | Cardiac Conduction |
| Cardiac Conduction | POSITIVELY CORRELATED WITH | Atrial Arrhythmia |
| Atrial Arrhythmia | MANIFESTATION OF | Atrial Fibrillation |
Reference: