Path ID: DB04846_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D017272 | Celiprolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UniProt:P07550 | Beta-2 adrenergic receptor | Protein |
| GO:0004016 | adenylate cyclase activity | BiologicalProcess |
| MESH:D000242 | Cyclic AMP | ChemicalSubstance |
| MESH:D002118 | Calcium | ChemicalSubstance |
| GO:0042311 | vasodilation | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Celiprolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Celiprolol | INCREASES ACTIVITY OF | Beta-2 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Adenylate Cyclase Activity |
| Beta-2 Adrenergic Receptor | POSITIVELY REGULATES | Vasodilation |
| Adenylate Cyclase Activity | INCREASES ABUNDANCE OF | Cyclic Amp |
| Cyclic Amp | DECREASES ABUNDANCE OF | Calcium |
| Calcium | REGULATES | Vasodilation |
| Vasodilation | NEGATIVELY CORRELATED WITH | Hypertension |
Reference:
- https://go.drugbank.com/drugs/DB04846#mechanism-of-action
- https://en.wikipedia.org/wiki/Celiprolol
- https://www.uniprot.org/uniprot/P08588#function
- https://www.uniprot.org/uniprot/P07550#function
- https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor#Antagonists
- https://en.wikipedia.org/wiki/Beta_blocker#%CE%B2-receptor_antagonism
- https://en.wikipedia.org/wiki/Beta2-adrenergic_agonist
- https://en.wikipedia.org/wiki/Hypertension