Path ID: DB04818_MESH_D003866_1

db04818-mesh-d003866-1

Concepts

Identifier Name Type
MESH:D007490 Iproniazid Drug
UniProt:P21397 Amine oxidase [flavin-containing] A Protein
UniProt:P27338 Amine oxidase [flavin-containing] B Protein
MESH:C044821 1-isopropylhydrazine ChemicalSubstance
GO:0042429 serotonin catabolic process BiologicalProcess
GO:0042420 dopamine catabolic process BiologicalProcess
MESH:D012701 Serotonin ChemicalSubstance
MESH:D004298 Dopamine ChemicalSubstance
HP:0000716 Depression PhenotypicFeature
MESH:D003866 Depressive Disorder Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Iproniazid DECREASES ACTIVITY OF Amine Oxidase [Flavin-Containing] A
Iproniazid DECREASES ACTIVITY OF Amine Oxidase [Flavin-Containing] B
Iproniazid HAS METABOLITE 1-Isopropylhydrazine
1-Isopropylhydrazine DECREASES ACTIVITY OF Amine Oxidase [Flavin-Containing] A
1-Isopropylhydrazine DECREASES ACTIVITY OF Amine Oxidase [Flavin-Containing] B
Amine Oxidase [Flavin-Containing] A POSITIVELY REGULATES Serotonin Catabolic Process
Amine Oxidase [Flavin-Containing] A POSITIVELY REGULATES Dopamine Catabolic Process
Amine Oxidase [Flavin-Containing] B POSITIVELY REGULATES Dopamine Catabolic Process
Serotonin Catabolic Process DECREASES ABUNDANCE OF Serotonin
Dopamine Catabolic Process DECREASES ABUNDANCE OF Dopamine
Serotonin NEGATIVELY CORRELATED WITH Depression
Dopamine NEGATIVELY CORRELATED WITH Depression
Depression MANIFESTATION OF Depressive Disorder

Comment: Iproniazid is withdrawn in USA due to interactions with tyrosine in food products.

Reference: