Path ID: DB04145_MESH_D006949_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D009540 | Nicotinyl alcohol | Drug |
| CHEBI:15940 | Nicotinic acid | ChemicalSubstance |
| UniProt:P49019 | Hydroxycarboxylic acid receptor 3 | Protein |
| UniProt:Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Protein |
| UniProt:Q96PD7 | Diacylglycerol O-acyltransferase 2 | Protein |
| MESH:D005227 | Fatty Acids | ChemicalSubstance |
| UniProt:P02656 | Apolipoprotein C-III | Protein |
| MESH:D015243 | Cholesterol, VLDL | ChemicalSubstance |
| MESH:D014280 | Triglycerides | ChemicalSubstance |
| MESH:D006949 | Hyperlipidemia | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Nicotinyl Alcohol | INCREASES ABUNDANCE OF | Nicotinic Acid |
| Nicotinic Acid | INCREASES ACTIVITY OF | Hydroxycarboxylic Acid Receptor 3 |
| Nicotinic Acid | INCREASES ACTIVITY OF | Hydroxycarboxylic Acid Receptor 2 |
| Nicotinic Acid | DECREASES ACTIVITY OF | Diacylglycerol O-Acyltransferase 2 |
| Hydroxycarboxylic Acid Receptor 3 | DECREASES ABUNDANCE OF | Fatty Acids |
| Hydroxycarboxylic Acid Receptor 2 | DECREASES ABUNDANCE OF | Fatty Acids |
| Diacylglycerol O-Acyltransferase 2 | INCREASES ABUNDANCE OF | Triglycerides |
| Fatty Acids | INCREASES ACTIVITY OF | Apolipoprotein C-Iii |
| Apolipoprotein C-Iii | POSITIVELY CORRELATED WITH | Cholesterol, Vldl |
| Cholesterol, Vldl | POSITIVELY CORRELATED WITH | Hyperlipidemia |
| Triglycerides | POSITIVELY CORRELATED WITH | Hyperlipidemia |
Comment: Nicotinyl alcohol has been shown to be metabolized rapidly to nicotinic acid (niacin) https://pubmed.ncbi.nlm.nih.gov/4883785/
Reference: