Path ID: DB02383_MESH_D048909_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C040550 | Tolrestat | Drug |
| UniProt:P15121 | Aldose reductase | Protein |
| MESH:D013012 | Sorbitol | ChemicalSubstance |
| GO:0006970 | Response to osmotic stress | BiologicalProcess |
| HP:0000518 | Cataract | PhenotypicFeature |
| MESH:D048909 | Diabetic complication | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Tolrestat | DECREASES ACTIVITY OF | Aldose Reductase |
| Aldose Reductase | INCREASES ABUNDANCE OF | Sorbitol |
| Sorbitol | CAUSES | Response To Osmotic Stress |
| Response To Osmotic Stress | POSITIVELY CORRELATED WITH | Cataract |
| Cataract | MANIFESTATION OF | Diabetic Complication |
Comment: Withdrawn
Reference: