Path ID: DB02329_MESH_D010437_1

db02329-mesh-d010437-1

Concepts

Identifier Name Type
MESH:D002229 carbenoxolone Drug
UniProt:P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Protein
UniProt:P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Protein
GO:0016491 oxidoreductase activity MolecularActivity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor MolecularActivity
MESH:D011453 Prostaglandins ChemicalSubstance
GO:0070254 mucus secretion BiologicalProcess
GO:0008283 cell population proliferation BiologicalProcess
GO:0001696 gastric acid secretion BiologicalProcess
MESH:D010437 Peptic ulcer Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Carbenoxolone NEGATIVELY REGULATES Corticosteroid 11-Beta-Dehydrogenase Isozyme 1
Carbenoxolone NEGATIVELY REGULATES 15-Hydroxyprostaglandin Dehydrogenase [Nad(+)]
Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 POSITIVELY REGULATES Oxidoreductase Activity
15-Hydroxyprostaglandin Dehydrogenase [Nad(+)] POSITIVELY REGULATES Oxidoreductase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor
Oxidoreductase Activity DECREASES ABUNDANCE OF Prostaglandins
Oxidoreductase Activity, Acting On The Ch-Oh Group Of Donors, Nad Or Nadp As Acceptor POSITIVELY REGULATES Prostaglandins
Prostaglandins POSITIVELY CORRELATED WITH Mucus Secretion
Prostaglandins POSITIVELY CORRELATED WITH Cell Population Proliferation
Prostaglandins NEGATIVELY CORRELATED WITH Gastric Acid Secretion
Mucus Secretion NEGATIVELY CORRELATED WITH Peptic Ulcer
Cell Population Proliferation NEGATIVELY CORRELATED WITH Peptic Ulcer
Gastric Acid Secretion POSITIVELY CORRELATED WITH Peptic Ulcer

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