Path ID: DB01744_MESH_D001416_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D002164 | camphor | Drug |
| UniProt:O75762 | Transient receptor potential cation channel subfamily A member 1 | Protein |
| GO:0050968 | detection of chemical stimulus involved in sensory perception of pain | BiologicalProcess |
| HP:0012531 | Pain | PhenotypicFeature |
| MESH:D001416 | Backache | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Camphor | DECREASES ACTIVITY OF | Transient Receptor Potential Cation Channel Subfamily A Member 1 |
| Camphor | NEGATIVELY CORRELATED WITH | Pain |
| Transient Receptor Potential Cation Channel Subfamily A Member 1 | REGULATES | Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain |
| Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain | CORRELATED WITH | Pain |
| Pain | MANIFESTATION OF | Backache |
Comment: Camphor is analgesic (https://www.genome.jp/dbget-bin/www_bget?cpd:C00808). The activation of members of the transient receptor ion channel protein family applications lead to desensitization, which in turn contributes to the analgesic effects of camphor after prolonged/repeated applications (https://pubmed.ncbi.nlm.nih.gov/33804078/).
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