Path ID: DB01708_MESH_D008180_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003687 | Prasterone | Drug |
| MESH:D008180 | Systemic lupus erythematosus | Disease |
| GO:0030521 | Androgen receptor signaling pathway | BiologicalProcess |
| UniProt:P10275 | Androgen receptor | Protein |
| GO:0071159 | NF-kappaB complex | CellularComponent |
| GO:0032635 | Interleukin-6 production | BiologicalProcess |
| GO:0002947 | Tumor necrosis factor receptor superfamily complex | CellularComponent |
| GO:0032612 | Interleukin-1 production | BiologicalProcess |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Prasterone | INCREASES ACTIVITY OF | Androgen Receptor |
| Androgen Receptor | PARTICIPATES IN | Androgen Receptor Signaling Pathway |
| Androgen Receptor Signaling Pathway | TREATS | Systemic Lupus Erythematosus |
| Prasterone | DECREASES ACTIVITY OF | Nf-Kappab Complex |
| Nf-Kappab Complex | POSITIVELY REGULATES | Interleukin-6 Production |
| Nf-Kappab Complex | POSITIVELY REGULATES | Tumor Necrosis Factor Receptor Superfamily Complex |
| Nf-Kappab Complex | POSITIVELY REGULATES | Interleukin-1 Production |
| Interleukin-6 Production | POSITIVELY CORRELATED WITH | Systemic Lupus Erythematosus |
| Tumor Necrosis Factor Receptor Superfamily Complex | POSITIVELY CORRELATED WITH | Systemic Lupus Erythematosus |
| Interleukin-1 Production | POSITIVELY CORRELATED WITH | Systemic Lupus Erythematosus |
Reference: