Path ID: DB01602_MESH_D010612_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C011674 | Bacampicillin | Drug |
| MESH:D000667 | Ampicillin | Drug |
| InterPro:IPR001460 | Penicillin-binding protein, transpeptidase | GeneFamily |
| GO:0018104 | Cross-linking of the peptidoglycan | BiologicalProcess |
| GO:0009273 | Peptidoglycan-based cell wall biogenesis | BiologicalProcess |
| GO:0005618 | Cell wall | CellularComponent |
| taxonomy:1314 | Streptococcus pyogenes | OrganismTaxon |
| MESH:D010612 | Pharyngitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Bacampicillin | HAS METABOLITE | Ampicillin |
| Ampicillin | DECREASES ACTIVITY OF | Penicillin-Binding Protein, Transpeptidase |
| Penicillin-Binding Protein, Transpeptidase | POSITIVELY REGULATES | Cross-Linking Of The Peptidoglycan |
| Cross-Linking Of The Peptidoglycan | POSITIVELY REGULATES | Peptidoglycan-Based Cell Wall Biogenesis |
| Peptidoglycan-Based Cell Wall Biogenesis | HAS OUTPUT | Cell Wall |
| Cell Wall | OCCURS IN | Streptococcus Pyogenes |
| Streptococcus Pyogenes | CAUSES | Pharyngitis |
Comment: Bacampicillin is an ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract.
Reference: