Path ID: DB01576_MESH_D009290_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003913 | Dexamfetamine | Drug |
| UniProt:P23975 | Sodium-dependent noradrenaline transporter | Protein |
| GO:0051620 | Norepinephrine uptake | BiologicalProcess |
| MESH:D009638 | Norepinephrine | ChemicalSubstance |
| UniProt:Q01959 | Sodium-dependent dopamine transporter | Protein |
| GO:0051583 | Dopamine uptake involved in synaptic transmission | BiologicalProcess |
| MESH:D004298 | Dopamine | ChemicalSubstance |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| UniProt:Q05940 | Synaptic vesicular amine transporter | Protein |
| GO:0015842 | Aminergic neurotransmitter loading into synaptic vesicle | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| MESH:D009290 | Narcolepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Dexamfetamine | DECREASES ACTIVITY OF | Sodium-Dependent Noradrenaline Transporter |
| Dexamfetamine | DECREASES ACTIVITY OF | Sodium-Dependent Dopamine Transporter |
| Dexamfetamine | DECREASES ACTIVITY OF | Synaptic Vesicular Amine Transporter |
| Sodium-Dependent Noradrenaline Transporter | POSITIVELY REGULATES | Norepinephrine Uptake |
| Norepinephrine Uptake | DECREASES ABUNDANCE OF | Norepinephrine |
| Sodium-Dependent Dopamine Transporter | POSITIVELY REGULATES | Dopamine Uptake Involved In Synaptic Transmission |
| Dopamine Uptake Involved In Synaptic Transmission | DECREASES ABUNDANCE OF | Dopamine |
| Dopamine | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Synaptic Vesicular Amine Transporter | POSITIVELY REGULATES | Aminergic Neurotransmitter Loading Into Synaptic Vesicle |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | DECREASES ABUNDANCE OF | Dopamine |
| Aminergic Neurotransmitter Loading Into Synaptic Vesicle | DECREASES ABUNDANCE OF | Norepinephrine |
| Norepinephrine | POSITIVELY CORRELATED WITH | Norepinephrine Secretion, Neurotransmission |
| Dopamine | POSITIVELY CORRELATED WITH | Dopamine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | TREATS | Narcolepsy |
| Dopamine Secretion, Neurotransmission | TREATS | Narcolepsy |
Reference: