Path ID: DB01545_MESH_D003866_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB01545 | Ethyl loflazepate | Drug |
| UniProt:P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | Protein |
| UniProt:P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | Protein |
| UniProt:P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | Protein |
| UniProt:P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | Protein |
| UniProt:P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | Protein |
| UniProt:Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | Protein |
| GO:0007214 | Gamma-aminobutyric acid signaling pathway | BiologicalProcess |
| HP:0000739 | Anxiety | PhenotypicFeature |
| HP:0000737 | Irritability | PhenotypicFeature |
| MESH:D003866 | Depressive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 |
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 |
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 |
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 |
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 |
| Ethyl Loflazepate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-3 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-4 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Signaling Pathway |
| Gamma-Aminobutyric Acid Signaling Pathway | NEGATIVELY CORRELATED WITH | Anxiety |
| Gamma-Aminobutyric Acid Signaling Pathway | NEGATIVELY CORRELATED WITH | Irritability |
| Anxiety | POSITIVELY CORRELATED WITH | Depressive Disorder |
| Irritability | POSITIVELY CORRELATED WITH | Depressive Disorder |
Comment: Illicit
Reference: