Path ID: DB01436_MESH_D012080_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C008088 | alfacalcidol | Drug |
| UniProt:O15528 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | Protein |
| MESH:D002117 | Calcitriol | ChemicalSubstance |
| UniProt:P11473 | Vitamin D3 receptor | Protein |
| UniProt:P19793 | Retinoic acid receptor RXR-alpha | Protein |
| GO:0045453 | bone resorption | BiologicalProcess |
| MESH:D002118 | Calcium | ChemicalSubstance |
| MESH:D012080 | Chronic Kidney Disease-Mineral and Bone Disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Alfacalcidol | MOLECULARLY INTERACTS WITH | 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial |
| 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial | INCREASES ABUNDANCE OF | Calcitriol |
| Calcitriol | INCREASES ACTIVITY OF | Vitamin D3 Receptor |
| Vitamin D3 Receptor | IN COMPLEX WITH | Retinoic Acid Receptor Rxr-Alpha |
| Retinoic Acid Receptor Rxr-Alpha | POSITIVELY REGULATES | Bone Resorption |
| Bone Resorption | POSITIVELY CORRELATED WITH | Calcium |
| Calcium | TREATS | Chronic Kidney Disease-Mineral And Bone Disorder |
Reference: