Path ID: DB01395_MESH_D059268_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C035144 | drospirenone | Drug |
| UniProt:P06401 | Progesterone receptor | Protein |
| reactome:R-HSA-9018519 | Estrogen-dependent gene expression | Pathway |
| HP:0030683 | Vaginitis | PhenotypicFeature |
| HP:0031088 | Vaginal dryness | PhenotypicFeature |
| MESH:D059268 | Atrophic vaginitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Drospirenone | POSITIVELY REGULATES | Progesterone Receptor |
| Progesterone Receptor | PARTICIPATES IN | Estrogen-Dependent Gene Expression |
| Estrogen-Dependent Gene Expression | NEGATIVELY CORRELATED WITH | Vaginal Dryness |
| Estrogen-Dependent Gene Expression | NEGATIVELY CORRELATED WITH | Vaginitis |
| Vaginitis | MANIFESTATION OF | Atrophic Vaginitis |
| Vaginal Dryness | MANIFESTATION OF | Atrophic Vaginitis |
Comment: Note that the combination therapy of estradiol and drospirenone would be more effective at treating atrophic vaginitis, than a mono-therapy relying on progestin only. Also, since many progestogens have off-target effects including estrogenic effects, the improvement in hot flashes maybe due to the drug binding to estrogen receptors instead.
Reference: