Path ID: DB01394_MESH_D010505_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003078 | colchicine | Drug |
| UniProt:P07437 | Tubulin beta chain | Protein |
| GO:1990266 | neutrophil migration | BiologicalProcess |
| GO:0016176 | superoxide-generating NADPH oxidase activator activity | MolecularActivity |
| GO:0030593 | neutrophil chemotaxis | BiologicalProcess |
| GO:0007266 | Rho protein signal transduction | BiologicalProcess |
| reactome:R-HSA-844456 | The NLRP3 inflammasome | Pathway |
| GO:0046785 | Microtubule polymerization | BiologicalProcess |
| CL:0000775 | Neutrophil | Cell |
| CL:0000576 | Monocyte | Cell |
| GO:0045087 | innate immune response | BiologicalProcess |
| GO:0070942 | neutrophil mediated cytotoxicity | BiologicalProcess |
| GO:0007266 | Rho protein signal transduction | BiologicalProcess |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | BiologicalProcess |
| UniProt:P01584 | Interleukin-1 beta | Protein |
| GO:0006954 | inflammatory response | BiologicalProcess |
| MESH:D010505 | Familial Mediterranean fever | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Colchicine | DECREASES ACTIVITY OF | Tubulin Beta Chain |
| Tubulin Beta Chain | POSITIVELY REGULATES | Microtubule Polymerization |
| Microtubule Polymerization | POSITIVELY REGULATES | The Nlrp3 Inflammasome |
| Microtubule Polymerization | POSITIVELY REGULATES | Rho Protein Signal Transduction |
| The Nlrp3 Inflammasome | POSITIVELY REGULATES | Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process |
| Rho Protein Signal Transduction | POSITIVELY REGULATES | Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process |
| Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process | INCREASES ABUNDANCE OF | Interleukin-1 Beta |
| Interleukin-1 Beta | PRODUCED BY | Neutrophil |
| Interleukin-1 Beta | PRODUCED BY | Monocyte |
| Colchicine | NEGATIVELY REGULATES | Neutrophil Migration |
| Colchicine | NEGATIVELY REGULATES | Superoxide-Generating Nadph Oxidase Activator Activity |
| Colchicine | NEGATIVELY REGULATES | Neutrophil Chemotaxis |
| Neutrophil Chemotaxis | POSITIVELY CORRELATED WITH | Neutrophil Mediated Cytotoxicity |
| Neutrophil Migration | POSITIVELY CORRELATED WITH | Neutrophil Mediated Cytotoxicity |
| Superoxide-Generating Nadph Oxidase Activator Activity | POSITIVELY CORRELATED WITH | Neutrophil Mediated Cytotoxicity |
| Neutrophil Mediated Cytotoxicity | CAUSED BY | Neutrophil |
| Neutrophil | PARTICIPATES IN | Innate Immune Response |
| Monocyte | PARTICIPATES IN | Innate Immune Response |
| Innate Immune Response | POSITIVELY CORRELATED WITH | Inflammatory Response |
| Inflammatory Response | MANIFESTATION OF | Familial Mediterranean Fever |
Reference: