Path ID: DB01388_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D020748 | mibefradil | Drug |
| UniProt:O43497 | Voltage-dependent T-type calcium channel subunit alpha-1G | Protein |
| UniProt:Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C | Protein |
| UniProt:O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | Protein |
| UniProt:Q01668 | Voltage-dependent L-type calcium channel subunit alpha-1D | Protein |
| UniProt:O60840 | Voltage-dependent L-type calcium channel subunit alpha-1F | Protein |
| UniProt:Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | Protein |
| UniProt:Q13698 | Voltage-dependent L-type calcium channel subunit alpha-1S | Protein |
| GO:0070509 | transmembrane calcium influx | BiologicalProcess |
| GO:0045907 | positive regulation of vasoconstriction | BiologicalProcess |
| GO:0008217 | Blood Pressure | BiologicalProcess |
| MESH:D006973 | Hypertension | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1F |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I |
| Mibefradil | DECREASES ACTIVITY OF | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1H | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1F | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1I | PARTICIPATES IN | Transmembrane Calcium Influx |
| Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S | PARTICIPATES IN | Transmembrane Calcium Influx |
| Transmembrane Calcium Influx | CONTRIBUTES TO | Positive Regulation Of Vasoconstriction |
| Positive Regulation Of Vasoconstriction | POSITIVELY REGULATES | Blood Pressure |
| Blood Pressure | POSITIVELY CORRELATED WITH | Hypertension |
Comment: Mibefradil was withdrawn from the market in 1998 because of potentially harmful interactions with other drugs
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