Path ID: DB01382_MESH_D003924_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C073263 | Glymidine | Drug |
| UniProt:P48048 | ATP-sensitive inward rectifier potassium channel 1 | Protein |
| GO:0051899 | Membrane depolarization | BiologicalProcess |
| GO:0005245 | Voltage-gated calcium channel activity | BiologicalProcess |
| GO:0070509 | Calcium ion import | BiologicalProcess |
| GO:0030073 | Insulin secretion | BiologicalProcess |
| MESH:D001786 | Blood Glucose | ChemicalSubstance |
| MESH:D003924 | Diabetes mellitus type 2 | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Glymidine | DECREASES ACTIVITY OF | Atp-Sensitive Inward Rectifier Potassium Channel 1 |
| Atp-Sensitive Inward Rectifier Potassium Channel 1 | NEGATIVELY CORRELATED WITH | Membrane Depolarization |
| Membrane Depolarization | POSITIVELY REGULATES | Voltage-Gated Calcium Channel Activity |
| Voltage-Gated Calcium Channel Activity | POSITIVELY REGULATES | Calcium Ion Import |
| Calcium Ion Import | POSITIVELY REGULATES | Insulin Secretion |
| Insulin Secretion | NEGATIVELY REGULATES | Blood Glucose |
| Blood Glucose | POSITIVELY CORRELATED WITH | Diabetes Mellitus Type 2 |
Reference: