Path ID: DB01380_MESH_D007634_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D003348 | cortisone acetate | Drug |
| UniProt:P04150 | Glucocorticoid receptor | Protein |
| UniProt:P23219 | COX Genes | Protein |
| UniProt:P04083 | lipocortin-1 | Protein |
| reactome:R-HSA-2162123 | Prostaglandin Synthesis | Pathway |
| MESH:D011453 | Prostaglandins | ChemicalSubstance |
| GO:0050900 | Immune Cell Funciton | BiologicalProcess |
| GO:0006954 | Inflammation | BiologicalProcess |
| MESH:D007634 | Keratitis | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Cortisone Acetate | INCREASES ACTIVITY OF | Glucocorticoid Receptor |
| Cortisone Acetate | INCREASES ABUNDANCE OF | Lipocortin-1 |
| Cortisone Acetate | DECREASES ABUNDANCE OF | Cox Genes |
| Glucocorticoid Receptor | INCREASES ABUNDANCE OF | Lipocortin-1 |
| Glucocorticoid Receptor | DECREASES ABUNDANCE OF | Cox Genes |
| Cox Genes | INCREASES ABUNDANCE OF | Prostaglandins |
| Lipocortin-1 | NEGATIVELY REGULATES | Immune Cell Funciton |
| Lipocortin-1 | NEGATIVELY REGULATES | Prostaglandin Synthesis |
| Prostaglandin Synthesis | PARTICIPATES IN | Inflammation |
| Prostaglandins | PARTICIPATES IN | Inflammation |
| Immune Cell Funciton | POSITIVELY REGULATES | Inflammation |
| Prostaglandin Synthesis | POSITIVELY REGULATES | Inflammation |
| Inflammation | CAUSES | Keratitis |
Reference: