Path ID: DB01367_MESH_D010300_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C031967 | rasagiline | Drug |
| MESH:D019208 | Brain-Derived Neurotrophic Factor | ChemicalSubstance |
| MESH:D051098 | Glial Cell Line-Derived Neurotrophic Factors | ChemicalSubstance |
| UniProt:P27338 | Amine oxidase [flavin-containing] B | Protein |
| UniProt:P10415 | Apoptosis regulator Bcl-2 | Protein |
| GO:0051402 | neuron apoptotic process | BiologicalProcess |
| GO:0022008 | neurogenesis | BiologicalProcess |
| GO:0042420 | dopamine catabolic process | BiologicalProcess |
| GO:0001963 | synaptic transmission, dopaminergic | BiologicalProcess |
| MESH:D010300 | Parkinson’s disease | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Rasagiline | INCREASES ABUNDANCE OF | Brain-Derived Neurotrophic Factor |
| Brain-Derived Neurotrophic Factor | POSITIVELY REGULATES | Neurogenesis |
| Rasagiline | INCREASES ABUNDANCE OF | Glial Cell Line-Derived Neurotrophic Factors |
| Glial Cell Line-Derived Neurotrophic Factors | POSITIVELY REGULATES | Neurogenesis |
| Neurogenesis | NEGATIVELY CORRELATED WITH | Parkinson’S Disease |
| Rasagiline | INCREASES ACTIVITY OF | Apoptosis Regulator Bcl-2 |
| Apoptosis Regulator Bcl-2 | NEGATIVELY REGULATES | Neuron Apoptotic Process |
| Neuron Apoptotic Process | POSITIVELY CORRELATED WITH | Parkinson’S Disease |
| Rasagiline | NEGATIVELY REGULATES | Amine Oxidase [Flavin-Containing] B |
| Amine Oxidase [Flavin-Containing] B | POSITIVELY REGULATES | Dopamine Catabolic Process |
| Dopamine Catabolic Process | CORRELATED WITH | Synaptic Transmission, Dopaminergic |
| Synaptic Transmission, Dopaminergic | CORRELATED WITH | Parkinson’S Disease |
Reference: