Path ID: DB01365_MESH_D007022_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D008616 | Mephentermine | Drug |
| UniProt:P35348 | Alpha-1A adrenergic receptor | Protein |
| UniProt:P35368 | Alpha-1B adrenergic receptor | Protein |
| UniProt:P25100 | Alpha-1D adrenergic receptor | Protein |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| GO:0060048 | Cardiac muscle contraction | BiologicalProcess |
| GO:0061533 | Norepinephrine secretion, neurotransmission | BiologicalProcess |
| MESH:D007022 | Low blood pressure | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Mephentermine | INCREASES ACTIVITY OF | Alpha-1A Adrenergic Receptor |
| Mephentermine | INCREASES ACTIVITY OF | Alpha-1B Adrenergic Receptor |
| Mephentermine | INCREASES ACTIVITY OF | Alpha-1D Adrenergic Receptor |
| Mephentermine | INCREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Alpha-1A Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1B Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Alpha-1D Adrenergic Receptor | POSITIVELY REGULATES | Vasoconstriction |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Cardiac Muscle Contraction |
| Vasoconstriction | NEGATIVELY CORRELATED WITH | Low Blood Pressure |
| Cardiac Muscle Contraction | NEGATIVELY CORRELATED WITH | Low Blood Pressure |
| Mephentermine | POSITIVELY REGULATES | Norepinephrine Secretion, Neurotransmission |
| Norepinephrine Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Low Blood Pressure |
Reference: