Path ID: DB01359_MESH_D006973_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D010394 | penbutolol | Drug |
| UniProt:P08588 | Beta-1 adrenergic receptor | Protein |
| UBERON:0000948 | Heart | GrossAnatomicalStructure |
| HP:0033533 | Increased cardiac output | PhenotypicFeature |
| UniProt:P00797 | Renin | Protein |
| UBERON:0002113 | Kidney | GrossAnatomicalStructure |
| GO:0042310 | Vasoconstriction | BiologicalProcess |
| GO:0008217 | Blood Pressure | BiologicalProcess |
| MESH:D006973 | Hypertensive disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Penbutolol | DECREASES ACTIVITY OF | Beta-1 Adrenergic Receptor |
| Beta-1 Adrenergic Receptor | LOCATED IN | Heart |
| Heart | POSITIVELY REGULATES | Increased Cardiac Output |
| Beta-1 Adrenergic Receptor | POSITIVELY REGULATES | Renin |
| Renin | LOCATED IN | Kidney |
| Kidney | POSITIVELY REGULATES | Vasoconstriction |
| Vasoconstriction | POSITIVELY REGULATES | Blood Pressure |
| Increased Cardiac Output | POSITIVELY CORRELATED WITH | Blood Pressure |
| Blood Pressure | POSITIVELY CORRELATED WITH | Hypertensive Disorder |
Reference: