Path ID: DB01356_MESH_D001714_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D016651 | Lithium carbonate | Drug |
| UniProt:P29218 | Inositol monophosphatase 1 | Protein |
| GO:0046855 | Inositol phosphate dephosphorylation | BiologicalProcess |
| MESH:D007294 | Inositol | BiologicalProcess |
| GO:0043647 | Inositol phosphate metabolic process | BiologicalProcess |
| GO:0014047 | Glutamate secretion | BiologicalProcess |
| UniProt:P4984 | Glycogen synthase kinase-3 beta | Protein |
| HP:0000713 | Agitation | PhenotypicFeature |
| GO:0061534 | Gamma-aminobutyric acid secretion, neurotransmission | BiologicalProcess |
| GO:0061527 | Dopamine secretion, neurotransmission | BiologicalProcess |
| GO:0004972 | NMDA glutamate receptor activity | MolecularActivity |
| MESH:D018698 | Glutamic Acid | ChemicalSubstance |
| MESH:D001714 | Bipolar disorder | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Lithium Carbonate | DECREASES ACTIVITY OF | Inositol Monophosphatase 1 |
| Inositol Monophosphatase 1 | POSITIVELY REGULATES | Inositol Phosphate Dephosphorylation |
| Inositol Phosphate Dephosphorylation | INCREASES ABUNDANCE OF | Inositol |
| Inositol | POSITIVELY REGULATES | Inositol Phosphate Metabolic Process |
| Inositol Phosphate Metabolic Process | POSITIVELY REGULATES | Glutamate Secretion |
| Glutamate Secretion | POSITIVELY CORRELATED WITH | Bipolar Disorder |
| Lithium Carbonate | DECREASES ACTIVITY OF | Glycogen Synthase Kinase-3 Beta |
| Glycogen Synthase Kinase-3 Beta | POSITIVELY CORRELATED WITH | Agitation |
| Agitation | OCCURS IN | Bipolar Disorder |
| Lithium Carbonate | POSITIVELY REGULATES | Gamma-Aminobutyric Acid Secretion, Neurotransmission |
| Gamma-Aminobutyric Acid Secretion, Neurotransmission | NEGATIVELY CORRELATED WITH | Bipolar Disorder |
| Lithium Carbonate | NEGATIVELY REGULATES | Dopamine Secretion, Neurotransmission |
| Dopamine Secretion, Neurotransmission | POSITIVELY CORRELATED WITH | Bipolar Disorder |
| Lithium Carbonate | NEGATIVELY REGULATES | Nmda Glutamate Receptor Activity |
| Nmda Glutamate Receptor Activity | POSITIVELY CORRELATED WITH | Glutamic Acid |
| Glutamic Acid | POSITIVELY CORRELATED WITH | Bipolar Disorder |
Reference: