Path ID: DB01349_MESH_D006973_1

db01349-mesh-d006973-1

Concepts

Identifier Name Type
MESH:C086167 tasosartan Drug
MESH:C415846 enoltasosartan ChemicalSubstance
UniProt:P30556 Type-1 angiotensin II receptor Protein
reactome:R-HSA-2022377 Renin-angiotensin-aldosterone system Pathway
GO:0003092 renal water retention BiologicalProcess
GO:0070294 renal sodium ion absorption BiologicalProcess
HP:0032263 Increased blood pressure PhenotypicFeature
GO:0042310 Vasoconstriction BiologicalProcess
GO:0035932 Aldosterone secretion BiologicalProcess
GO:0003095 Pressure natriuresis BiologicalProcess
UBERON:0001235 Adrenal cortex GrossAnatomicalStructure
HP:0000822 Blood pressure PhenotypicFeature
MESH:D006973 Hypertensive disorder Disease

Relationships

NOTE: predicates are annotated in Biolink Model (v1.3.0)

Subject Predicate Object
Tasosartan HAS METABOLITE Enoltasosartan
Enoltasosartan NEGATIVELY REGULATES Type-1 Angiotensin Ii Receptor
Type-1 Angiotensin Ii Receptor POSITIVELY REGULATES Renin-Angiotensin-Aldosterone System
Renin-Angiotensin-Aldosterone System POSITIVELY CORRELATED WITH Vasoconstriction
Renin-Angiotensin-Aldosterone System POSITIVELY REGULATES Renal Water Retention
Renin-Angiotensin-Aldosterone System POSITIVELY REGULATES Renal Sodium Ion Absorption
Renal Sodium Ion Absorption POSITIVELY CORRELATED WITH Increased Blood Pressure
Renal Water Retention POSITIVELY CORRELATED WITH Increased Blood Pressure
Vasoconstriction POSITIVELY CORRELATED WITH Increased Blood Pressure
Increased Blood Pressure AFFECTS RISK FOR Hypertensive Disorder
Type-1 Angiotensin Ii Receptor POSITIVELY REGULATES Aldosterone Secretion
Aldosterone Secretion LOCATED IN Adrenal Cortex
Adrenal Cortex POSITIVELY REGULATES Pressure Natriuresis
Pressure Natriuresis POSITIVELY REGULATES Blood Pressure
Blood Pressure MANIFESTATION OF Hypertensive Disorder

Reference: