Path ID: DB01320_MESH_D004827_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:C043114 | fosphenytoin | Drug |
| MESH:D010672 | Phenytoin | ChemicalSubstance |
| InterPro:IPR001696 | Voltage gated sodium channel, alpha subunit | GeneFamily |
| GO:0098870 | action potential propagation | BiologicalProcess |
| HP:0001250 | Seizure | PhenotypicFeature |
| MESH:D004827 | Epilepsy | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Fosphenytoin | HAS METABOLITE | Phenytoin |
| Phenytoin | DECREASES ACTIVITY OF | Voltage Gated Sodium Channel, Alpha Subunit |
| Voltage Gated Sodium Channel, Alpha Subunit | POSITIVELY REGULATES | Action Potential Propagation |
| Action Potential Propagation | CONTRIBUTES TO | Seizure |
| Seizure | MANIFESTATION OF | Epilepsy |
Comment: Fosphenytoin is a prodrug of phenytoin used for the treatment of epileptic seizures.
Reference: