Path ID: DB01307_MESH_D003920_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| MESH:D000069057 | insulin detemir | Drug |
| UniProt:P06213 | Insulin receptor | Protein |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | MolecularActivity |
| UniProt:P31749 | RAC-alpha serine/threonine-protein kinase | Protein |
| MESH:D011493 | Protein Kinase C | Protein |
| UniProt:P14672 | Solute carrier family 2, facilitated glucose transporter member 4 | Protein |
| GO:0046323 | glucose import | BiologicalProcess |
| MESH:D003920 | Diabetes mellitus | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Insulin Detemir | INCREASES ACTIVITY OF | Insulin Receptor |
| Insulin Receptor | POSITIVELY REGULATES | Transmembrane Receptor Protein Tyrosine Kinase Activity |
| Transmembrane Receptor Protein Tyrosine Kinase Activity | POSITIVELY REGULATES | Rac-Alpha Serine/Threonine-Protein Kinase |
| Rac-Alpha Serine/Threonine-Protein Kinase | POSITIVELY REGULATES | Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 |
| Rac-Alpha Serine/Threonine-Protein Kinase | POSITIVELY REGULATES | Protein Kinase C |
| Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 | POSITIVELY REGULATES | Glucose Import |
| Protein Kinase C | POSITIVELY REGULATES | Glucose Import |
| Glucose Import | NEGATIVELY CORRELATED WITH | Diabetes Mellitus |
Reference: