Path ID: DB01285_MESH_D013036_1
Concepts
| Identifier | Name | Type |
|---|---|---|
| DB:DB01285 | corticotropin | Drug |
| UniProt:Q01718 | Adrenocorticotropic hormone receptor | Protein |
| CHEBI:65312 | corticotropin-releasing hormone (human) | ChemicalSubstance |
| HP:0001250 | Seizure | PhenotypicFeature |
| HP:0012469 | Infantile spasms | PhenotypicFeature |
| MESH:D013036 | West syndrome | Disease |
Relationships
NOTE: predicates are annotated in Biolink Model (v1.3.0)
| Subject | Predicate | Object |
|---|---|---|
| Corticotropin | POSITIVELY REGULATES | Adrenocorticotropic Hormone Receptor |
| Adrenocorticotropic Hormone Receptor | DECREASES EXPRESSION OF | Corticotropin-Releasing Hormone (Human) |
| Corticotropin-Releasing Hormone (Human) | POSITIVELY CORRELATED WITH | Seizure |
| Adrenocorticotropic Hormone Receptor | NEGATIVELY CORRELATED WITH | Infantile Spasms |
| Seizure | MANIFESTATION OF | West Syndrome |
| Infantile Spasms | MANIFESTATION OF | West Syndrome |
Reference:
- https://go.drugbank.com/drugs/DB01285#BE0000848
- https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201610/
- https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone_(medication)#Medical_uses
- https://pubmed.ncbi.nlm.nih.gov/11701250/
- https://pubmed.ncbi.nlm.nih.gov/23606552/
- https://pubmed.ncbi.nlm.nih.gov/16781824/
- https://pubmed.ncbi.nlm.nih.gov/11261504/